Cusco, the ancient capital of the Inca Empire, is the starting point for visiting Machu Picchu, Ausangate, Rainbow Mountain, Salkantay, and more. To adjust to the altitude, it's recommended to arrive at least two days in advance and take shorter tours in Cusco, like visiting the historic center, Qorikancha, and nearby archaeological sites such as Sacsayhuamán and Tambomachay. Afterward, it's ideal to explore the Sacred Valley, including Pisac and Ollantaytambo. Once acclimated, you can venture to higher-altitude spots like Rainbow Mountain, Humantay Lake, and the Seven Lakes of Ausangate to fully enjoy each destination.